The Gospel of Christ and the teachings of his Church guide the work of the USCCB. The work of the Conference is rooted in three general mission goals and organized into three key areas of responsibility.
- To act collaboratively and consistently on vital issues confronting the Church and society
- To foster communion with the Church in other nations, within the Church universal, under the leadership of its supreme pastor, the Roman Pontiff
- To offer appropriate assistance to each bishop in fulfilling his particular ministry in the local Church